Project information
New trends in electrochemistry of nucleic acids and their applications in enviromental chemistry
- Project Identification
- GA203/02/0422
- Project Period
- 1/2002 - 12/2004
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Science
- Cooperating Organization
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Institute of Biophysics
- Responsible person RNDr. František Jelen, CSc.
Electrochemical methods represent fast and inexpensive approach in studies of structure, interactions and properties of biomacromolecules. In this project modem electrochemical techniques will be applied in connection with mercury and solid electrodes to study oligonucleotides and nucleic acids and then-interactions with some drugs and carcinogens. Information on the adsorption and redox properties of oligonucleotides with respect to their nucleotide sequences and lengths will be obtained. Electrochemica studies will concentrate also on interaction of the nucleic acids strands at the electrode surface aimed for developing sensors for various kind of nucleic acid damage and detection of genotoxic compounds in environment.
Publications
Total number of publications: 59
2004
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The protonation/deprotonation equilibrium of thymidine and azidothymidine studied by UV spectra and multivariate curve resolution
sborník- XLVII Zjazd PTchem i SITPChem Wroclaw 2004, year: 2004
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Využití katalytických reakcí na rtuťových elektrodách pro elektrochemické stanovení metalothioneinu
Chemick Listy, year: 2004, volume: 98, edition: 2
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Využití avidin-biotinové technologie pro elektrochemickou detekci nukleových kyselin
Sborník příspěvků VIII. pracovní setkání biochemiků a molekulárních biologů, year: 2004
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Využití elektrochemických metod pro stanovení metalothioneinu a fytochelatinu
Sborník abstrakt IV. pracovní setkání fyzikálních chemiků a elektrochemiků, year: 2004
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Využití katalytických reakcí na rtuťové elektrodě pro elektrochemické stanovení metalothioneinů
Chem. listy, year: 2004, volume: 2004, edition: 98
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Využitie eliminačnej voltametrie pri štúdiu redukcie kadmia na rozličných elektrodach
Moderní elektrochemické metody, year: 2004
2003
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Application of Elimination Voltammetry to the Resolution of Adenine and Cytosine Signals in Oligonucleotides. I. Homo-oligodeoxynucleotides dA9 and dC9
Electroanalysis, year: 2003, volume: 19, edition: 15
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Application of avidin-biotin technology and adsorptive transfer stripping square-wave voltammetry for detection of DNA hybridization and avidin in transgenic avidin maize
Analytical Chemistry, year: 2003, volume: 75, edition: 11
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Application of elimination voltammetry with linear scan in bioelectrochemistry
The role of electrochemistry in sustained development of modern societies, 54 th ISE Meeting, year: 2003
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Electrochemical detection of chromosomal translocation T (15;17) as an acute promyelotic leukemie marker
Sborník příspěvků, VII. pracovní setkání biochemiků a molekulárních biologů, year: 2003