Project information
Structure-functional Relationships of Haloalkane Dehalogenases
- Project Identification
- GAP207/12/0775
- Project Period
- 1/2012 - 12/2016
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Science
- Cooperating Organization
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University of South Bohemia České Budějovice
Proposed project is continuation of a very productive cooperation between the Institute of Physical Biology University of South Bohemia and the Loschmidt Laboratories at Masaryk University. This cooperation has started in 2006 within the project of Centre for Biocatalysis and Biotransformation LC06010 supported by the Czech Ministry of Education. This project has yielded 7 joint impacted publications and more than 30 conference contributions during the past 6 years. Moreover, 5 Ph.D. theses will be finished during 2010-2013. To keep high standard for this running collaboration, we would like to continue with the research project in the framework of GACR project named “Structure-Functional Relationships of Haloalkane Dehalogenases“.
Publications
Total number of publications: 23
2013
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Cation-Specific Effects on Enzymatic Catalysis Driven by Interactions at the Tunnel Mouth.
Journal of Physical Chemistry B, year: 2013, volume: 117, edition: 21, DOI
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Crystallographic Analysis of New Psychrophilic Haloalkane Dehalogenases: DpcA from Psychrobacter cryohalolentis K5 and DmxA from Marinobacter sp. ELB17
Acta Crystallographica, year: 2013, volume: 2013, edition: F69, DOI
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Differences in crystallization of two LinB variants from Sphingobium japonicum UT26
Acta Crystallographica, year: 2013, volume: 69, edition: Pt 3, DOI
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DspA from Strongylocentrotus purpuratus: the First Biochemically Characterized Haloalkane Dehalogenase of Non-Microbial Origin.
Biochimie, year: 2013, volume: 95, edition: 11, DOI
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Engineering Enzyme Stability and Resistance to an Organic Cosolvent by Modification of Residues in the Access Tunnel
Angewandte Chemie International Edition, year: 2013, volume: 52, edition: 7, DOI
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Gates of Enzymes.
Chemical Reviews, year: 2013, volume: 113, edition: 8, DOI
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Haloalkane dehalogenases: Biotechnological applications
Biotechnology Journal, year: 2013, volume: 8, edition: 1, DOI
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Immobilization of Haloalkane Dehalogenase LinB from Sphingobium japonicum UT26 for Biotechnological Applications
Journal of Biocatalysis & Biotransformation, year: 2013, volume: 2, edition: 2
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Organic Co-solvents Affect Activity, Stability and Enantioselectivity of Haloalkane Dehalogenases
Biotechnology Journal, year: 2013, volume: 8, edition: 6, DOI
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Release of Halide Ions from the Buried Active Site of the Haloalkane Dehalogenase LinB Revealed by Stopped-Flow Fluorescence Analysis and Free Energy Calculations.
Journal of Physical Chemistry B, year: 2013, volume: 117, edition: 46, DOI