Project information
Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
- Project Identification
- MSM0021622430
- Project Period
- 1/2007 - 12/2013
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Other MU Faculty/Unit
- Faculty of Science
- Other MU Faculty/Unit
- Faculty of Informatics
- Other MU Faculty/Unit
- Central European Institute of Technology
- Keywords
- embryonic stem cells
The goal of this project will be a) to profit from availability of unique cellular resources - mouse and human embryonic stem cells and normal and malignant hematopoietic stem/progenitor cells, b) to effectively employ a wide variety of current and complementary methodologies available to the consortium, and c) to exploit a proven/certified expertise in working with various living systems that span from in vitro cultured cells, through animal models to oncohematological patients. All this together will represent a powerful experimental platform aimed at addressing a nature of molecules and molecular mechanisms underlaying phenomena that are common to both normal and cancer stem cells, mainly their ability to self-renew and to enter differentiation pathways. Integral part of this general goal is to implement multifaceted analytical approach that will cover studies of gene expression at both mRNA and protein levels, evaluating function of extra and intracellular signaling pathways, and analyzing biological properties of cells in vitro and in vivo. Expected outcome will be not only understanding but also a definition of molecules and/or molecular pathways to be tested as therapeutic targets, and cellular models that will make such testing feasible.
Publications
Total number of publications: 357
2010
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Distribution of Heavy Metals in the Liver of Foetuses and Female Mice after Oral Administration during Pregnancy, a Histochemical Study
Acta Veterinaria, year: 2010, volume: 2010, edition: 79
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DNA damage response in human embryonic stem cells: Impact of long-term propagation
Year: 2010, type: Conference abstract
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Evaluation of minimal residual disease in patients with chronis lymphocytic leukemia by multiparametric flow cytometry and real-time PCR
Year: 2010, type: Conference abstract
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FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence
Bone, year: 2010, volume: neuveden, edition: 47
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Frekvence mutací v BCR-ABL kinázové doméně u pacientů s chronickou myeloidní leukémií (CML) léčených tyrozinkinázovými inhibitory - zkušenosti IHOK FN Brno
Year: 2010, type: Conference abstract
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Gene-expression profile of steroid-refractory acute Graft-versus-host disease.
Year: 2010, type: Conference abstract
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Genetic Interaction Between Lrp6 and Wnt5a During Mouse Development
Developmental dynamics, year: 2010, volume: 2010, edition: 239
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Genomic stability of stem cells - why should we care
Year: 2010, type: Conference abstract
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Growth/differentiation factor-15 is an abundant cytokine in human seminal plasma
Hum. Reprod., year: 2010, volume: 25, edition: 12
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High Expression of Lymphocyte-Activation Gene 3 in Chronic Lymphocytic Leukemia Cells is Associated with Unmutated IGHV and Reduced Treatment-Free Survival.
The journal of molecular diagnostics., year: 2010, volume: 12, edition: 3