Project information
Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
- Project Identification
- MSM0021622430
- Project Period
- 1/2007 - 12/2013
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Other MU Faculty/Unit
- Faculty of Science
- Other MU Faculty/Unit
- Faculty of Informatics
- Other MU Faculty/Unit
- Central European Institute of Technology
- Keywords
- embryonic stem cells
The goal of this project will be a) to profit from availability of unique cellular resources - mouse and human embryonic stem cells and normal and malignant hematopoietic stem/progenitor cells, b) to effectively employ a wide variety of current and complementary methodologies available to the consortium, and c) to exploit a proven/certified expertise in working with various living systems that span from in vitro cultured cells, through animal models to oncohematological patients. All this together will represent a powerful experimental platform aimed at addressing a nature of molecules and molecular mechanisms underlaying phenomena that are common to both normal and cancer stem cells, mainly their ability to self-renew and to enter differentiation pathways. Integral part of this general goal is to implement multifaceted analytical approach that will cover studies of gene expression at both mRNA and protein levels, evaluating function of extra and intracellular signaling pathways, and analyzing biological properties of cells in vitro and in vivo. Expected outcome will be not only understanding but also a definition of molecules and/or molecular pathways to be tested as therapeutic targets, and cellular models that will make such testing feasible.
Publications
Total number of publications: 357
2010
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High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity
Nature Biotechnology, year: 2010, volume: 28, edition: 4
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Histochemický průkaz těžkých kovů po perorální aplikaci v játrech samic a jejich fétů u laboratorní myši (Mus musculus var. alba)
Odkaz Ladzianskeho pre budúce generácie, year: 2010
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Human embryonic stem cells - signs of an adaptation as a response to long term in vitro cultivation
Year: 2010, type: Conference abstract
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Human Embryonic Stem Cells Are Capable of Executing G1/S Checkpoint Activation
Stem Cells, year: 2010, volume: 28, edition: 7, DOI
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Human embryonic stem cells are capable of executing G1/S checkpoint activation.
Year: 2010, type: Conference abstract
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Characteristic of molecular changes coupled to differentiation pathways in human embryonic stem cells
Year: 2010, type: Conference abstract
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Chronic Lymphocytic Leukemia and Focusing on Epidemiology and Management in Everyday Hematologic Practice: Recent Data From the Czech Leukemia Study Group for Life (CELL)
Clinical Lymphoma, Myeloma & Leukemia, year: 2010, volume: 10, edition: 4
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Increasing hematopoietic microchimerism is a reliable indicator of incipient AML relapse
International Journal of Laboratory Hematology, year: 2010, volume: 33, edition: 1
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Inhibition of Notch Signaling in Human Embryonic Stem Cell-Derived Neural Stem Cells Delays G1/S Phase Transition and Accelerates Neuronal Differentiation In Vitro and In Vivo
Stem Cells, year: 2010, volume: 28, edition: 5, DOI
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Interactions with the microenvironment protect lymphoma B-cells from rituximab induced apoptosis and could represent a therapeutic target.
Year: 2010, type: Conference abstract