Project information
Application of computer image analysis in optical microscopy
- Project Identification
- MSM 143300002
- Project Period
- 1/1999 - 12/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Informatics
- Keywords
- image analysis; image processing; segmentation; preprocessing; deconvolution; 3D analysis; 3D reconstruction; mathematical morphology; parallel computing; parallel algorithms; optical microscopy; confocal microscopy; automation; automated microscopy
Aim: The aim of the project is the research in the field of computer analysis of microscopic images, in the field of automation of the acquisition process and on-line image analysis and application of gained knowledge in praxis. The proposal assumes both continuation of running research of cell nucleus structure with clinical applications in diagnostics and prevention of leukemias and other cancer diseases as well as extension of the research into other application areas of computer analysis of microscopic images, biomedical as well as industrial. Content: Especially the algorithms of image preprocessing and segmentation will be studied with emphasis on deconvolution of 3D images, mathematical morphology operations and 3D image reconstruction from a series of 2D image slices. An intensive research will be led also in the area of parallel image analysis algorithms and parallelization of selected algorithms on multi-processor workstations using the equipment of Supercomputing centre MU.
Results
The aim of the project is the research in the field of computer analysis of microscopic images, in the field of automation of the acquisition process and on-line image analysis and application of gained knowledge in praxis.
Publications
Total number of publications: 88
2006
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Localization of genetic elements of intact and derivative chromosome 11 and 22 territories in nuclei of Ewing sarcoma cells
Journal of Structural Biology, year: 2006, volume: 155, edition: 3
2005
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Image acquisition and its automation in fluorescence microscopy
From cells to proteins: Imaging nature across dimensions, year: 2005, number of pages: 44 s.
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Segmentace buněk v biomedicínském obraze pomocí genetických algoritmů
Kognícia a umelý život V., year: 2005
2004
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Applications of Image Registration in Human Genome Research
Computer Vision and Mathematical Methods in Medical and Biomedical Image Analysis, year: 2004
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Automated acquisition and processing of multidimensional image data in confocal in vivo microscopy
Microscopy research and technique, year: 2004, volume: 64, edition: 2
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Automated confocal microscopy: The way of achieving both quality and quantity in 3D image cytometry
International Symposium on Biomedical Imaging, year: 2004
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Automated confocal microscopy: The way of achieving both quality and quantity in 3D image cytometry
Year: 2004, type:
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Automated image analysis in fluorescence microscopy: From isolated cells to tissues and microarray images
Biophysics of the Genome, year: 2004
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Automated in vivo imaging of cell interior using fluorescent proteins
Year: 2004, type: Conference abstract
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Biophysics of the Genome
Year: 2004, type: Workshop