Project information
Application of computer image analysis in optical microscopy
- Project Identification
- MSM 143300002
- Project Period
- 1/1999 - 12/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Informatics
- Keywords
- image analysis; image processing; segmentation; preprocessing; deconvolution; 3D analysis; 3D reconstruction; mathematical morphology; parallel computing; parallel algorithms; optical microscopy; confocal microscopy; automation; automated microscopy
Aim: The aim of the project is the research in the field of computer analysis of microscopic images, in the field of automation of the acquisition process and on-line image analysis and application of gained knowledge in praxis. The proposal assumes both continuation of running research of cell nucleus structure with clinical applications in diagnostics and prevention of leukemias and other cancer diseases as well as extension of the research into other application areas of computer analysis of microscopic images, biomedical as well as industrial. Content: Especially the algorithms of image preprocessing and segmentation will be studied with emphasis on deconvolution of 3D images, mathematical morphology operations and 3D image reconstruction from a series of 2D image slices. An intensive research will be led also in the area of parallel image analysis algorithms and parallelization of selected algorithms on multi-processor workstations using the equipment of Supercomputing centre MU.
Results
The aim of the project is the research in the field of computer analysis of microscopic images, in the field of automation of the acquisition process and on-line image analysis and application of gained knowledge in praxis.
Publications
Total number of publications: 88
2004
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Towards a Fully Automated Tissue Cell Segmentation Method
Visualization, Imaging, and Image Processing, year: 2004
2003
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3D Object reconstructions in image cytometry
Biophysics of the Genome, year: 2003
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A network solution for high-resolution image cytometry
Biophysics of the Genome, year: 2003
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Analysis of DNA methylation status of cell nuclei using high-resolution
Biophysics of the Genome, year: 2003
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Architecture of chromosomal territories in apoptotic cells
Biophysics of the Genome, year: 2003
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Arrangement of chromosome 11 and 22 territories, EWSR1 and FLI-1 genes, and other genetic elements of these chromosomes in human lymphocytes and Ewing sarcoma cells
Human Genetics, year: 2003, volume: 112, edition: 2
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Cytogenetics and cytology of retinoblastomas
J Cancer Res. Clin.Oncol., year: 2003, volume: 129, edition: 2
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Chromosomal territory segmentation in apoptotic cells
Cellular and Molecular Life Sciences, year: 2003, volume: 60, edition: 5
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Improving measurement precision using automated micro-axial tomography
Biophysics of the Genome, year: 2003
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Multilevel Adaptive Thresholding and Dual Simplex Mesh Deformation as a Tool for Tissue Reconstruction
Visualization, Imaging, and Image Processing, year: 2003