Project information
Application of computer image analysis in optical microscopy
- Project Identification
- MSM 143300002
- Project Period
- 1/1999 - 12/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Informatics
- Keywords
- image analysis; image processing; segmentation; preprocessing; deconvolution; 3D analysis; 3D reconstruction; mathematical morphology; parallel computing; parallel algorithms; optical microscopy; confocal microscopy; automation; automated microscopy
Aim: The aim of the project is the research in the field of computer analysis of microscopic images, in the field of automation of the acquisition process and on-line image analysis and application of gained knowledge in praxis. The proposal assumes both continuation of running research of cell nucleus structure with clinical applications in diagnostics and prevention of leukemias and other cancer diseases as well as extension of the research into other application areas of computer analysis of microscopic images, biomedical as well as industrial. Content: Especially the algorithms of image preprocessing and segmentation will be studied with emphasis on deconvolution of 3D images, mathematical morphology operations and 3D image reconstruction from a series of 2D image slices. An intensive research will be led also in the area of parallel image analysis algorithms and parallelization of selected algorithms on multi-processor workstations using the equipment of Supercomputing centre MU.
Results
The aim of the project is the research in the field of computer analysis of microscopic images, in the field of automation of the acquisition process and on-line image analysis and application of gained knowledge in praxis.
Publications
Total number of publications: 88
2001
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Deterministic modeling of the chromatin organization in human cell nuclei
Shaping future with simulation, year: 2001
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Exchange aberrations among 11 chromosomes of human lymphocytes induced by gamma-rays
International Journal of Radiation Biology, year: 2001, volume: 77, edition: 4
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FISH Imaging
Confocal and two-photon microscopy: Foundations, applications, and advances, year: 2001, number of pages: 41 s.
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Spatial distribution of selected genetic loci in nuclei of human leukemia cells after irradiation
Radiation Research, year: 2001, volume: 155, edition: 2
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Spherical Object Reconstruction Using Star-Shaped Simplex Meshes
Energy Minimization Methods in Computer Vision and Pattern Recognition, year: 2001
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Struktura chromatinu vyššího řádu v interfázních jádrech buněk lidské krve
Year: 2001, number of pages: 113 s.
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Theoretical versus experimental resolution in optical microscopy
Microscopy research and technique, year: 2001, volume: 53, edition: 2, DOI
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Využití počítačové analýzy obrazu v moderní cytometrii
Year: 2001, type: Conference abstract
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Způsob stanovení vlastností buněk metodou cytometrie s vysokým rozlišením a zařízení pro jeho provádění
Publisher: Úřad průmyslového vlastnictví ČR, state: Czech Republic, patent's number: 288693, year: 2001
2000
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Advances in high-resolution cytometry of FISH dots in interphase cell nuclei
Year: 2000, type: Conference abstract